No hassle, just more protein
Increased yield
Our Switcher Technology enables you to get more recombinant protein from bacteria.
Easier optimisation
The technology is robust to use and optimisation of expression is quick.
Keep your expression system
Our technology can simply be added to your favourite production strain.
News
10 December 2021
Here is a short video about us!
What we do, why we believe in it, and who we are.
11 November 2021
Gearbox Biosciences in EIT Jumpstarter Grand Final
Since June 2021 we have been part of EIT Jumpstarter business training program. We have successfully progressed through two evaluation stages to the Grand Final pitching competition in 1st of December 2021.
11 November 2021
We are being incubated
We are happy to be accepted to S2B Launchpad business incubator by Tartu Science Park. Under supervision of two experienced mentors and loads of networking opportunities, we believe to boost our startup readiness.
Switcher Technology
Gearbox Biosciences has developed a robust switch that allows us to control bacterial growth with high precision. Our patent pending Switcher Technology is based on induced removal of origin of replication from bacterial chromosome. Switched cells do not divide but remain metabolically active, which enables to decouple protein production from cellular growth.
Switching significantly increases the protein productivity in bacterial cells because switched cells do not “waste” resources on growth but channel majority of them for product synthesis. In lab environment a recombinant protein expression is upregulated 2 – 5 times without any other optimisation.
More detailed overview of our technology can be found from the preprint of our research publication https://doi.org/10.1101/2021.12.07.471534
Team
Gearbox Biosciences is a spin-off company from University of Tartu, Estonia and we are a team of technical founders. We are committed to turn this compelling invention into viable business to increase the use of sustainable resources.
Collaborations
Contact
Interested in trying our technology on your protein?
Reach us:
OÜ Gearbox Biosciences
Office: Nooruse 1, Tartu, Estonia
Email: info [at] gearbox.bio