Antibiotic-free bioproduction
Our technology allows to produce recombinant proteins in E. coli without antibiotics
High expression of target protein
Our Switcher Technology enables to get high expression of recombinant proteins
News
1 September 2022
Teamed up with ArcticZymes for technology testing
Enzymes are biological engines and essential tools in many industries from food processing to pharmaceuticals. However, some of them are difficult to produce. That’s why ArcticZymes Technologies ASA and Gearbox Biosciences teamed up for a joint test project to tackle the production of difficult-to-express enzymes.
25 January 2022
Starting a cooperation project with Solis Biodyne
We are happy to announce the start of a cooperation project with a premier PCR reagent manufacturer Solis BioDyne! We will jointly test whether our Switcher Technology can increase the production yield of Solis’ proteins at a time, when literally everyone in the world needs PCR testing.
Solis BioDyne has been developing and producing life science reagents since 1995, having become one of the leading temperature stable reagent suppliers in Europe today. They create world-changing molecular solutions and help scientists to solve their greatest challenges.
10 December 2021
Here is a short video about us!
What we do, why we believe in it, and who we are.
Technology
Gearbox Biosciences has developed a robust switch that allows us to control bacterial growth with high precision. Our patent pending Switcher Technology is based on induced removal of origin of replication from bacterial chromosome. Switched cells do not divide but remain metabolically active, which enables to decouple protein production from cellular growth.
Switching significantly increases the protein productivity in bacterial cells because switched cells do not “waste” resources on growth but channel majority of them for product synthesis. In lab environment a recombinant protein expression is upregulated 2 – 5 times without any other optimisation.
More detailed overview of our technology can be found from our research publication here
Team
Gearbox Biosciences is a spin-off company from University of Tartu, Estonia.
Collaborations
Contact
Our technology is available for licensing.
Interested in trying our tech on your protein?